Single MHC Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding
نویسندگان
چکیده
منابع مشابه
T Cell Receptor–MHC Interactions up Close
I MHC molecules the peptide, usually derived from proteins in the cytoplasm of any cell, is generated by the proteasome, transported into the endoplasmic reticuJens Hennecke and Don C. Wiley Department of Molecular and Cellular Biology Harvard University and lum, loaded onto MHC molecules, and presented on the Howard Hughes Medical Institute cell surface to the surveillance system of circulatin...
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alphabeta T cell receptors (TCRs) can crossreact with both self- and foreign- major histocompatibility complex (MHC) proteins in an enigmatic phenomenon termed alloreactivity. Here we present the 2.35 A structure of the 2C TCR complexed with its foreign ligand H-2L(d)-QL9. Surprisingly, we find that this TCR utilizes a different strategy to engage the foreign pMHC in comparison to the manner in...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2007
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2007.07.028